科学研究
近年,学院在基础研究和应用研究领域取得丰硕成果。学院以东北师范大学为第一单位在National Science Review、Nature Structural & Molecular Biology、Nature Aging、Nature Communications、Proc. Natl. Acad. Sci. USA等国内外一流期刊发表论文700余篇,得到同行专家的认可;以第一完成单位获得国家及省部级科技奖励11项;获批专利47项,5项专利完成成果转化,转化金额1500万元;获批新品种4项,其中2项推广种植。代表性成果如下:
以第一单位发表的代表性论文(按时间倒叙排列):
1、邹莹莹;裴嘉瑶;龙海珍;蓝丽婷;董克俭;王婷婷;李明;赵哲萱;朱丽润;张港旋;金鑫;王杨;温增麒;魏民;冯云鹏*;H4S47 O-GlcNAcylation regulates the activation of mammalian replication origins,NATURE STRUCTURAL & MOLECULAR BIOLOGY,2023,30,800-811
2、张娜;胡倩颖;隋婷婷;付璐;张兴林;王钰;朱筱娟;黄百渠;陆军*;李占军*;张瑜*;Unique progerin C-terminal peptide ameliorates Hutchinson–Gilford progeria syndrome phenotype by rescuing BUBR1,Nature Aging,2023,3:185–201
3、张敏娜;Manuel Delgado-Baquerizo;李广胤;Forest Isbell;王悦;Yann Hautier;王瑶;肖盈丽;蔡金婷;潘晓斌;王岭*,Experimental impacts of grazing on grassland biodiversity and function are explained by aridity,Nature Communications,2023,14:5040
4、张可人;赵雪茹;赵越;张志斌;刘智剑;刘子昱;于亚男;李居祚;马艺荞;董岳璠;庞淅;金鑫;李宁;刘宝;Jonathan F. Wendel;翟继先;龙艳萍*;王天雅*;宫磊*;Cell type-specific cytonuclear coevolution in three allopolyploid plant species,P NATL ACAD SCI USA,2023,120,40,e2310881120
5、杨小飞;于昊澎; Susan Duncan;张月莹;Jitender Cheema;刘海峰;J. Benjamin Miller;张洁;Chun Kit Kwok; 张铧坤*;丁一倞*,RNA G-quadruplex structure contributes to cold adaptation in plants,Nature Communications,2022,13:6224
6、李长平;丁宝旭;马欣彤;杨萱;王红艳;董岳璠;张志斌;王金宾;李晓宠;于亚男;于祎洋;刘宝;Jonathan F. Wendel;李一丹*;王天雅*;宫磊*;A temporal gradient of cytonuclear coordination of chaperonins and chaperones during RuBisCo biogenesis in allopolyploid plants,P NATL ACAD SCI USA,2022,119:34:2200106119
7、吴莹;林凡;周瑶;王婕;孙帅;王斌;张志斌;李过;林秀云;王旭彤;孙阅;董芊里;徐春明;宫磊*;Jonathan F. Wendel*;张志武*;刘宝*;Genomic mosaicism due to homoeologous exchange generates extensive phenotypic diversity in nascent allopolyploids,NATIONAL SCIENCE REVIEW,2021,8:5:nwaa277
8、赵子翰;许雪娇;程海荣;Michelle C. Miller;何真;古洪铭;张中玉;Avraham Raz;Kevin H. Mayo;台桂花*;周义发*;Galectin-3 N-terminal tail prolines modulate cell activity and glycan-mediated oligomerization/ phase separation,P NATL ACAD SCI USA,2021,118:19:e2021074118
9、郝凤奇;田苗苗;张鑫波;金鑫;蒋英;孙雪;王杨;彭平辉;刘佳;夏超义;冯云鹏*;魏民*;Butyrate enhances CPT1A activity to promote fatty acid oxidation and iTreg differentiation,P NATL ACAD SCI USA,2021,118:22:e2014681118
10、张志斌;勾晓婉;寻红卫;卞瑶;马欣彤;李居祚;李宁;宫磊;Feldman Moshe;刘宝*;Levy Avraham A* ,Homoeologous exchanges occur through intragenic recombination generating novel transcripts and proteins in wheat and other polyploids,P NATL ACAD SCI USA,2020,117:25:14561-14571
以第一单位获得的代表性奖励:
1、吉林省科学技术奖自然科学奖一等奖,DNA甲基化对水稻基因转录、染色质构型稳定性和农业性状的影响,宫磊,刘宝,李宁,徐春明,王旭彤,孙阅,吴莹,张志斌,董芊里, 2022;
2、吉林省科学技术奖自然科学奖一等奖,染色体和基因组稳定性与多倍体小麦物种形成,刘宝,张铧坤,李霖锋,杨春武,亓宝,赵娜,朱博,卞瑶,李宁,韩方普,2020;
3、吉林省科学技术奖自然科学奖一等奖,细胞恶性转化的表观遗传学机制研究,陆军,张瑜,姚若斯,张建超,赵黎,侯平甫,杜娟,孔晨飞,董智雄,黄百渠,2017;
4、吉林省科技成果转化贡献奖,第二届吉林省科技成果转化贡献奖(贡献个人),孙琳,2021;
5、第十六届中国青年科技奖,中国青年科技奖,宫磊,2020.
以第一单位获批的代表性专利:
1、一种制备单唾液酸四己糖神经节苷脂的方法,周义发,高娟,原野,及莉,冷佳益,陈红磊,台桂花,ZL201410254826.0;(已转化)
2、一种具有唾液酸水解酶活性的蛋白质的制备方法,周义发,高娟,原野,及莉,台桂花,ZL201410254870.1;(已转化)
3、一种人参多糖的提取方法及其在制备降血糖药物和食品中的应用,台桂花,周义发,孙琳,孙成新,吴迪,ZL201410084031.X;(已转化)
4、Use of Ethyl p-Methoxycinnamate and Derivatives thereof in Maintaining Self-Renewal and Pluripotency of Stem Cells,鲍永利,李玉新,秦洪双,AU2017100034A4;
5、血竭素、血竭素衍生物或其可用盐在制备糖尿病药物中的应用,孙陆果,李玉新,刘磊,梅普成,鲍永利,朱红,侯美玲,任书静,ZL201710089562.1。
以第一单位获批的代表性新品种:
1、东盛山野豌豆(穆春生, 金成吉, 李志坚, 吴春英, 王俊锋,2021)
2、’东草1号’羊草(穆春生, 王俊锋, 石玉杰,2021)
3、’东燕1号’燕麦(周帮伟, 李志坚, 王俊锋, 王 岭, 王建永,2021)
4、 ‘东苜2号’紫花苜蓿(李志坚, 穆春生, 周帮伟, 巴雷, 王俊锋,2017)